One simple exercise proved older adults can build and retain muscle – and caused a paradigm shift in science

In 1988, 712 people lived at the Hebrew Rehabilitation Center for the Aged, a Boston nursing home affectionately named “Hebrew rehab” by its residents and staff. The residents’ average age was 88, and three-quarters of them were women. Every resident had multiple medical conditions. Almost half required help to engage in the essential activities of daily life: getting out of bed, going to the bathroom, bathing, walking, eating. But they were survivors. Some had survived the Holocaust. Others fled the Cossacks. They all lived through the Great Depression.

They were ideal research subjects for Maria Fiatarone, a young doctor and faculty member in geriatric medicine at both Tufts and Harvard. In terrible shape, with lifetimes of practice overcoming great challenges: to Fiatarone, they were perfect.