Jamie George is a doubt for England’s Six Nations opener against Ireland in Dublin after limping out of Saracens’ Champions Cup defeat by Castres with a hamstring injury to cap a miserable week for the former national captain.

George, who was replaced by Maro Itoje as England captain last Tuesday, was introduced as a second-half replacement here but could do little to stop Saracens letting the match slip through their fingers, ensuring they face an away fixture at Toulon in the last 16.

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